A sepsis “bundle” refers to a series of responses that a medical team takes in order to treat sepsis. There is a three-hour bundle and six-hour bundle, both of which include different steps, including specific testing, and administering IV fluids and antibiotics.

The purpose of the bundle is to make sepsis treatment more standardized for hospital teams to implement. The bundles were created by the Surviving Sepsis Campaign of the Society of Critical Care Medicine. The campaign has the goal of decreasing the amount of sepsis-related deaths by 25%. Individual hospitals can adjust protocols slightly to meet geographical differences in bacterial susceptibility to antibiotics, but the core of the bundles remain largely unchanged from hospital to hospital for simplicity and improved accuracy of treatment.